Narcolepsy Mac OS

Narcolepsy Osa
Narcolepsy Mac Os Download
Narcolepsy Microsleep
Narcolepsy Mac Os 11

Mac OS Leopard 10.5.4 Install Disc. From Anthony, following up on Leopard on a Digital Audio Power Mac: Dear Charles, Thank you for getting back to me so quickly! Okay, what I've got here is a CD install disc for Mac OS X version 10.5.4. We've determined that I need another RAM chip, as I only have 256 MB built-in memory. Thanks for all the. Narcolepsy is a disorder in which the sleep-wake cycle is significantly altered.Its central symptom is excessive daytime sleepiness (EDS), which may involve falling asleep involuntarily, even while eating or driving.

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Home > Queens College > Publications and Research > 411

Publications and Research

Title

Authors

Document Type

Article

Publication Date

2020

Abstract

Narcolepsy Osa

Attention deficit hyperactive disorder (ADHD) is a highly heritable neurodevelopmental disorder, and excessive daytime sleepiness is frequently observed in ADHD patients. Excessive daytime sleepiness is also a core symptom of narcolepsy and essential hypersomnia (EHS), which are also heritable conditions. Psychostimulants are effective for the symptomatic control of ADHD (primary recommended intervention) and the two sleep disorders (frequent off-label use). However, the common biological mechanism for these disorders has not been well understood. Using a previously collected genome-wide association study of narcolepsy and EHS, we calculated polygenic risk scores (PRS) for each individual. We investigated a possible genetic association between ADHD and narcolepsy traits in the Hamamatsu Birth Cohort for mothers and children (HBC study) (n=876). Gene-set enrichment analyses were used to identify common pathways underlying these disorders. Narcolepsy PRS were significantly associated with ADHD traits both in the hyperactivity domain (e.g.,P-value threshold < 0.05,β[SE], 5.815 [1.774];P=0.002) and inattention domain(e.g.,P-value threshold < 0.05,β[SE], 5.734 [1.761];P=0.004). However, EHS PRS was not significantly associated with either domain of ADHD traits. Gene-set enrichment analyses revealed that pathways related to dopaminergic signaling, immune systems, iron metabolism, and glial cell function involved in both ADHD and narcolepsy. Findings indicate that ADHD and narcolepsy are genetically related, and there are possible common underlying biological mechanisms for this relationship. Future studies replicating these findings would be warranted to elucidate the genetic vulnerability for daytime sleepiness in individuals with ADHD.